Study of DNA methyl transferase 3A mutation in acute myeloid leukemic patients
نویسندگان
چکیده
منابع مشابه
Leukemic Blasts From Patients With Acute Myeloid Leukemias
A CUTE LEUKEMIAS are regarded as disorders characterized by a diffenentiative block of the hemopoietic precursors, which results in an unnegulated accumulation of immature blood cells.”2 Several in vitro experiments have shown that this block can be overcome by a wide variety ofchemical compounds;”3 based on these reports, new strategies of treatment have been proposed for leukemia therapy. Suc...
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Acute myeloid leukemia (AML) is a clonal hematopoietic stem/progenitor cell disorder which features several genetic mutations. Recurrent genetic alterations identified in AML are recognized as causes of the disease, finding application as diagnostic, prognostic and monitoring markers, with potential use as targets for cancer therapy. Here, we performed a pyrosequencing technique to investigate ...
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Background: HOX genes are an exceedingly preserved family of homeodomain-involving transcription factors. They are related to a number of malignancies, comprising acute myeloid leukemia (AML). This study aimed to evaluate the effect of HOXB1 7bp deletion mutation on HOXB1gene expression in 36 individuals. Materials and Methods: The present cross-sectional study was done on a large Iranian fami...
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ژورنال
عنوان ژورنال: Egyptian Journal of Medical Human Genetics
سال: 2018
ISSN: 1110-8630
DOI: 10.1016/j.ejmhg.2018.05.005